Pence Middle East trip to go ahead amid Jerusalem outrage
Aides said Pence is to travel to Cairo and Jerusalem from Tuesday, amid demonstrations and diplomatic tensions over the dramatic shift in US policy.
President Donald Trump's administration invited almost universal condemnation earlier this month when it officially recognised Jerusalem and effectively ignored Palestinian claims on the city.
The city's status had been seen as a central element of any eventual peace deal.
Palestinian, Coptic and other leaders have said Pence is not welcome and have publicly rebuffed requests for a meeting.
Any plans that Pence - who is known to be deeply religious - may have had to make the pilgrimage to Bethlehem also appear to have been thwarted.
The US vice president will however address the Knesset and meet the Israeli and Egyptian leaders Binyamin Netanyahu and Abdel Fattah el-Sisi during the five day trip.