A pre-dawn attack near a farm in the Saihat area of Qatif, on the Gulf coast in eastern Saudi Arabia has killed two Saudi police officers.
A ministry spokesman said the suspect or suspects had not immediately been identified.
It is the latest incident in the area as police continue to hunt suspects on a list of 23 wanted people issued in 2011 after Shiite unrest.
Last week, two Indian passersby and a policeman were wounded when police came under fire from a farming area in Qatif.
Many suspects on the wanted list have already been detained or killed in shootouts.