Iran launched dozens of pilotless aircraft at targets in Israel, after Israeli strikes killed dozens in an 1 April attack on consulate in the Syrian capital Damascus.
An Israeli army official said Iran had launched more than 200 attack drones and ballistic missiles at Israel.
Iran's allies in the region joined the attack with Yemen's Houthi rebels also launching drones at Israel, according to security agency Ambrey, and Lebanon's Hezbollah movement announcing rocket fire at Israeli positions in the annexed Golan Heights.
The official IRNA news agency said the attack had dealt "heavy blows" to an air base in the Negev desert, but the Israeli army said there had only been minor damage.