More than 100 Palestinians were killed in an Israeli "massacre" on Gaza's southern Rafah city, Wafa reported early on Monday.
"Israel is officially continuing to target civilians and transfer the war to Rafah to push the population to get displaced under bombardment," it said in a statement released on X.
"The recent massacres of the occupation are evidence of the validity of international warnings and fears of catastrophic results of the expansion of the war to Rafah," the ministry added.
Rafah, which sits on Gaza's border with Egypt, is currently hosting over one million displaced Palestinians who were forced to evacuate by Israel from northern and central Gaza.
The Israeli army on Sunday approved a plan for a ground offensive in Rafah.
Since 7 October, Israel's war on the besieged enclave has killed over 28,000 people - mostly women and children.