Assad arrived in the Red Sea coastal city of Jeddah on Thursday for the Arab League gathering, his first since the bloc suspended Syria in 2011 over his regime's brutal crackdown on pro-democracy demonstrators that led to a conflict which killed over 500,000 people.
"We express our happiness and pleasure to be on the kingdom's soil. This summit is very important," Syrian Foreign Minister Faisal Mekdad said after reaching Jeddah earlier this week, adding that the Syrian delegation was "here to make this summit a success".
The summit in Saudi Arabia comes at a time when the world's biggest oil exporter is flexing its diplomatic muscle across the Middle East and beyond.
It follows a frenetic stretch of high-stakes diplomacy triggered by the kingdom's surprise Chinese-brokered rapprochement deal with Iran announced in March.
Since then, Saudi Arabia has restored bilateral ties with the Syrian regime - an ally of Iran - and ramped up a push for peace in Yemen, where it leads a military coalition against the Iran-backed Houthi rebels.
Riyadh also played a leading role in evacuating civilians from Sudan when fighting erupted there last month, and it is currently hosting representatives of Sudan's warring parties in a bid to hammer out a ceasefire.
"The Kingdom of Saudi Arabia has become, in the eyes of all observers, the peacemaker and the icon of harmony, calling for an end to differences and the elimination of conflicts," Kuwaiti writer Jawad Ahmed Bukhamseen gushed in an op-ed this week in the private Saudi newspaper Okaz.
But not every country in the region has been eager to mend ties with Assad.
Qatar said this month it would not normalise relations with Assad's government but also noted this would not be "an obstacle" to Arab League reintegration.
On Thursday, the emir of Qatar, a fierce critic of the Syrian leader, announced he would lead the Gulf state's delegation to Jeddah.
While the Qatari government has called for accountability for "war crimes" in Syria, the emir made no comment on Qatar's expectations for the summit.
Beyond challenges facing the Middle East, the Arab League summit should also take on issues like the war in Ukraine and "the global economic crisis", Khaled Manzlawiy, the bloc's assistant secretary general for political affairs, wrote on Wednesday in the Asharq Al-Awsat newspaper.
"Indeed, the entire world is undergoing a perilous stage in history as the maps of international relations are redrawn," he wrote, adding that Arab unity can give the region "a voice that is heard not only in the region but also across the globe".
That jibes with Saudi Arabia's recent moves to diversify its global ties, deepening relations with China and coordinating with Russia on oil policy even as it maintains a close bond with the United States, its long time security partner.
Global preoccupation with the war in Ukraine could amount to "a kiss of life for the League to play its role as a coordinating station for efforts to resolve conflicts in the region," Egyptian analyst Rabha Seif Allam told AFP.
From Riyadh's perspective, a successful summit would involve concrete commitments from Syria on issues including war refugees and captagon trade, said Torbjorn Soltvedt of the risk intelligence firm Verisk Maplecroft.
Yet Arab League summits "have more often than not been characterised by internal disagreement and indecisiveness," he added.
"The bar for success will therefore be low."